Neural Tube Defects: Review of Experimental Evidence on Stem Cell Therapy and Newer Treatment Options
ثبت نشده
چکیده
The failure of closure of the neural tube during development leads to malformations called neural tube defects (NTDs). The most common neural malformations in humans include anencephaly, encephalocele, exencephaly, craniorachischisis spina bifida with or without myelomeningocele, lipomyeloschisis, lipomyelomeningocele, meningocele and myelocystocele. Current preventive strategies are mainly based on pharmacologic/folic acid supplementation. However, stem cell-based and other combination approaches may emerge as potential treatment options for NTDs. This review provides an account of experimental evidence on stem cell therapy and newer treatment options for NTDs which have become available in recent years. Copyright © 2010 S. Karger AG, Basel
منابع مشابه
Neural tube defects: review of experimental evidence on stem cell therapy and newer treatment options.
The failure of closure of the neural tube during development leads to malformations called neural tube defects (NTDs). The most common neural malformations in humans include anencephaly, encephalocele, exencephaly, craniorachischisis spina bifida with or without myelomeningocele, lipomyeloschisis, lipomyelomeningocele, meningocele and myelocystocele. Current preventive strategies are mainly bas...
متن کاملNeural Tube Defects: Review of Experimental Evidence on Stem Cell Therapy and Newer Treatment Options
The failure of closure of the neural tube during development leads to malformations called neural tube defects (NTDs). The most common neural malformations in humans include anencephaly, encephalocele, exencephaly, craniorachischisis spina bifida with or without myelomeningocele, lipomyeloschisis, lipomyelomeningocele, meningocele and myelocystocele. Current preventive strategies are mainly bas...
متن کاملO 9: Immunomodulatory Effects of Neural Stem Cell on Multiple Sclerosis: A Systematic Review
Multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), are chronic inflammatory demyelinating disorders of central nervous system (CNS). While the cause is unclear, the fundamental mechanism is thought to be destruction of myelin sheaths of neurons through immune system. One of the approaches being proposed in EAE therapy is neural stem cells (NSCs) trans...
متن کاملClinical Applicability of Stem Cell Therapy in Dental Diseases: A Systematic Review of Available Clinical Trials
Background: Developing cell-based therapeutic methods for the differentiation of various stem cells to the dental tissues could be a revolutionary step towards the use of cell therapy for dental disease. In the present study, we aimed to systematically review the literature to establish the efficiency of stem cells in treatment of various dental diseases. Methods: A literature search was perfo...
متن کاملP 111: Use of Stem Cell Therapy for Treatment of Temporal Lobe Epilepsy (TLE)
Epilepsy is one of the most common neuroinflammatory disorders that affect more than 50 million people worldwide. Excessive electrical discharges in neurons following neural cell damage or loss leads to recurrent seizures, which are described as epilepsy. One of the most common and difficult to treat types of epilepsy is Temporal Lobe Epilepsy (TLE), which results from hippocampal sclerosis. Cu...
متن کامل